Renaissance BioScience Corp., a leader in yeast bioengineering, announced a new project funded by Genome BC to extend its RNA interference (RNAi) biopesticide technology from above-ground insect pests to soil-dwelling crop pests, starting with wireworms. This project marks a significant step in developing a precision biopesticide for wireworms, which are among the most destructive soil pests globally.
Wireworms, the larvae of click beetles, damage crops like potatoes, corn, and cereals by feeding on seeds, seedlings, and roots below ground. Their subterranean lifestyle makes them difficult to control with conventional methods. Renaissance's yeast-based RNAi platform aims to deliver double-stranded RNA that silences essential genes in the pests. The company has successfully applied this technology to foliar pests, but adapting it for soil conditions presents unique challenges, such as protecting the RNA from degradation and ensuring ingestion by wireworms.
Dr. John Husnik, co-CEO and Chief Scientific Officer, emphasized the strategic importance: "Wireworms spend up to five years underground, where control options are limited. This project will determine how our yeast platform can be extended to soil-dwelling pests, opening doors to new agricultural applications." The project targets Agriotes species, focusing on conserved essential genes to create a multi-species product.
The funding from Genome BC supports the development of environmentally sustainable alternatives to chemical pesticides. "This support recognizes the potential of precision biological technologies to transform sustainable agriculture," said Dr. Husnik. Success could lead to RNAi products for a wide range of soil insects, expanding Renaissance's portfolio and addressing global demand for eco-friendly pest control.
Renaissance's platform builds on previous successes against above-ground pests. By combining yeast-based delivery with advanced formulations, the company aims to overcome barriers to soil-applied RNAi. For more information, visit Renaissance BioScience and Genome BC.
